سائنسی مضمون 🇬🇧 Mentions KS

Is ZNF462 at 9q31.2 a Novel Kallmann Syndrome Gene?

person Hyung-Goo Kim, Soo-Hyun Kim, Mi-Hyeon Jang, and Lawrence C. Layman

calendar_today Jan 23, 2026

This mini-review argues that ZNF462, known for Weiss-Kruszka syndrome, may also be linked to Kallmann syndrome and delayed puberty. Several reported cases with ZNF462 loss showed hormone-related features, including growth hormone deficiency, cryptorchidism, and delayed puberty, suggesting ZNF462 may affect hypothalamic-pituitary-gonadal development.