Is ZNF462 at 9q31.2 a Novel Kallmann Syndrome Gene?

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This mini-review argues that ZNF462, known for Weiss-Kruszka syndrome, may also be linked to Kallmann syndrome and delayed puberty. Several reported cases with ZNF462 loss showed hormone-related features, including growth hormone deficiency, cryptorchidism, and delayed puberty, suggesting ZNF462 may affect hypothalamic-pituitary-gonadal development.

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