Scientific Article 🇬🇧 Directly KS related

Balancing Methylation: Developing KDM4B Inhibitors as Potential Treatment for Kleefstra Syndrome

person Ellen van den Berg, Katrin Linda, Anthony Tumber, et al.

calendar_today Jun 23, 2026

Researchers are exploring KDM4B inhibitors as a lab-stage potential Kleefstra treatment. The approach aims to rebalance histone methylation disrupted by EHMT1 deficiency, with candidate compounds screened in the lab and tested in iPSC-derived neurons using MEA recordings. (Page 53)