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NLGN3 autism variants have distinct functional impact on synapses and sleep behavior in Drosophila

person Rebekah E. Townsley et al., PLOS Genetics
calendar_today Oct 16, 2026

In this research article, scientists modeled three autism-linked NLGN3 gene variants in fruit flies. Different variants changed sleep, synapse structure (connections between nerve cells), or vesicle dynamics in different ways, suggesting NLGN3 variants are not functionally equivalent.

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